TECH OFFER

Encapsulation of Living cells for Cell Therapy and Biotech

KEY INFORMATION

TECHNOLOGY CATEGORY:
Healthcare - Pharmaceuticals & Therapeutics
Life Sciences - Industrial Biotech Methods & Processes
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TECHNOLOGY READINESS LEVEL (TRL):
LOCATION:
Singapore
ID NUMBER:
TO174465

TECHNOLOGY OVERVIEW

This cell encapsulation technology is unique, versatile, and can be applied for a wide range of applications. It enables encapsulation of live eukaryotic cells in biologically-inert cellulose capsules.

The membranes of the capsules are permeable, allowing for free diffusion of nutrients/growth media across the membrane into the capsule, and the release of any bio-factors produced by the encapsulated cells. As a result, the cells can grow, fill-up and remain viable inside the capsules. This enables very high cell-to-capsule material ratio and is one of the main advantages over other technologies together with the capability for cryopreservation and long-term storage.

The technology provider is equipped to produce GMP-compliant capsules containing eukaryotic cells as medical cell therapy products. Scientific data with clinical studies have confirmed that when grafted into humans, these capsules do not elicit immune response, which is the major obstacle faced by other encapsulation strategies. These capsules have been shown to be efficacious in bringing about the desired effects of cell-based therapy and are therefore the ideal mode for localized/systemic delivery of therapeutic products allowing a one-for-all “off the shelf” product.

The technology provider is seeking partners who have interests in this bioencapsulation technology for GMP-certified living cells and released bio-factor related products, e.g. cell lines, stem cells.

TECHNOLOGY FEATURES & SPECIFICATIONS

This technology consists of microparticles containing live eukaryotic cells. Each capsule (0.5 - 1mm) is seeded with a few hundred mammalian cells, which can be cultured under optimal growth conditions. Upon capsule filling-up due to cell growth, each capsule can contain tens of thousands of the chosen therapeutic cells.

A wide range of eukaryotic cells can be capsulated using this technology. Once the capsules are filled with cells, they can be frozen for long-term storage or transportation. The frozen capsules can be subsequently thawed to revive the activity of the capsulated cells with very high viability (even over years). These capsules can be implanted into humans or animal patients for cell-based therapies. The capsules shield the encapsulated cells from host immunity, while allowing for the release of bio-therapeutic products from the encapsulated cells. If required, the capsules can be removed from the site of implant later after therapy is completed.

Using a proprietary decapsulation solution, the capsule membrane can be dissolved to release the cells for certain applications such as growth of cells in bioreactors. Release from capsules in this way also allows for quality control tests and measurements.

POTENTIAL APPLICATIONS

Applications of capsules containing eukaryotic cells

  • Healthcare

Capsules encapsulated with cells meant for cell-based therapy can be easily grafted in patients. The capsules keep the encapsulated cells localised and facilitate safe implantation of cells conducive for long term production of therapeutic molecules in vivo.

  • Biotechnology

The capsules protect cells in bioreactors from sheer forces and stresses and simplify the purification of released bioproducts, leading to significant reduction in production costs.

  • Logistics

The capsules allow the cells to be frozen and stored for long periods. When needed the capsules can be unfrozen to re-activate the cells without loss of viability.

 

Unique Value Proposition

  • For mammalian cells, the capsules can be frozen and thawed without any damage to the capsules
  • Capsules enable extended storage possibilities due to higher stability and viability over time
  • Capsules are completely non-immunogenic
  • Capsules can be dissolved to release cells alive for testing and QC assays
  • One-stop-shop for technology and manufacturing
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