Formulation for Shrimp Culling & Immunity Augmentation


Life Sciences - Agriculture & Aquaculture
Sustainability - Food Security


Specificity and memory are two major features of the immune system vaccination targets in general. However, the shrimp’s immunity has limited specificity and lacks long-term memory. This poses a challenge to disease prevention, increasing the complexity of health and disease management in shrimp farming. Persistent and emerging disease outbreaks have forced many farmers to employ chemicals and antibiotics to combat specific pathogens. However, this is not sustainable and it increases the risk of contamination to both the environment and humans.

To improve shrimp resilience, immunostimulants have been gaining interest as an environmentally safe alternative. However, published correlations of in vitro and in vivo lab studies are unable to translate to practical applications.

This technology is employed to cull weak and diseased fry before stocking into farm ponds, using proprietary epigenetic activated fermentation (EpAF) technology. The formulated mix consists of all-natural ingredients and is antibiotics-free & GMO-free. It can be applied to all phases of shrimp aquaculture, from broodstock, hatchery, to grow-out stages for higher survival rates and a more profitable harvest safe for human consumption.

The technology provider is looking for joint venture partners or licensing the technology to interested parties from the aquaculture industry.


This biotechnology can be applied in two phases, preferably at the earliest possible stage in the hatchery.

Phase 1 - Culling: Fries that are inherently weaker or diseased are removed within a few days.

Phase 2 Growth Boost: Certain growth-promoting receptors within the shrimp are activated to increase their growth rates.

The technology sustains immunity throughout the culture cycle and periodic growth genes are activated for robust growth. The healthy fry will appear robust and translucent, with cleaner exoskeletons signifying healthier internal systems.

The grow-out stage will experience higher survival rates (> 85% right after the culling stage) and harvests in a shorter culture time (20 - 30 days faster for shrimps and 3 - 5 months for fish eels), with a lower Feed Conversion Ratio (FCR).

In this way, the technology acts as a selection pressure for the immunologically strong shrimps for growth enhancement, so as to increase farming productivity and reduce harvest loss.


This technology is mainly applied for improving the immunity of the fry batch, but can be extended to the following:

  1. Development of stronger broodstock to produce higher quality eggs by mitigating inherent diseases within the brooders before spawning (both fish & shrimp)
  2. Immune boost to grow-out ponds for faster growth and shorter harvest time

Market Trends & Opportunities

Over the last two decades, worldwide shrimp farming has suffered outbreaks of diseases mainly caused by bacteria (Vibrio), viruses (WSSV), and protozoa (EHP) resulting in huge losses. As aquaculture rises in importance for its contribution to the global food supply and security, it is important to invest in stronger and more reliable methods of diseases prevention and control.

In Singapore, most of the aquaculture starts from imported post larvae (PLs). This technology can act as an additional filter to sieve out healthy fry before the actual rearing starts to increase productivity and reduce the impact of any disease outbreaks thereafter. This in turn helps to reduce harvest loss and production costs for the farmers. Additionally, this technology can be of interest to brooders farmers to develop healthier brooders, producing healthier offsprings and thereby lowering downstream costs and higher harvest yields.

Furthermore, there has been increasing interests consumers have in the harvest and production of the food they consume. More emphasis has been placed on sustainable and clean technology as the aquaculture scene evolves.


  • All natural; antibiotics- free & GMO-free disease prevention measure
  • Reduces production costs from rearing diseased or immunologically weak fry by allowing them to be excluded from the pond stocking
  • Prevent mass mortalities happening in the grow-out stage
  • Improved feed conversion ratio
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